O. I. Horyn, H. I. Falfushynska


Green synthesis of nanoparticles using environmental-friendly reducing agents is in the focus. We applied green technology for the synthesis of zinc nanoparticles (nZnO) using leaves extract of Catharanthus roseus and fruits extract of Momordica charantia (Karela). The development and advance of nZnO biosynthesis from leaves and fruits extracts of target medicinal plants was observed by UV/VIS spectroscopy. The peaks were determined at 355 and 365 nm for nZnO synthesized from the leaf extracts of M. charantia and C. roseus correspondingly. Synthetized nanoparticles have demonstrated antiradical capacity against 2,2-diphenyl-1-picrylhydrazyl and towards 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) in physiologically relevant concentration. Synthesized nZnO using Catharanthus roseus and Momordica charantia extracts reflected the same optical, antioxidant and antihyperglycemic (Horyn et al., 2019) characteristics and could be applied in the fields of medical and pharmaceuticals for formulation of new drugs.


Green synthesis; nano zinc oxide; Catharanthus roseus; Momordica charantia; antiradical capacity

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A calcium channel blocker nifedipine distorts the effects of nano-zinc oxide on metal metabolism in the marsh frog Pelophylax ridibundus / Falfushynska H., Gnatyshyna L., Horyn O. [et al.] // Saudi J Biol Sci. – 2019. – Vol. 26, Issue 3. – P. 481–489. DOI: 10.1016/j.sjbs.2017.10.004

A resonance light scattering ratiometry applied for binding study of organic small molecules with biopolymer / Huang C. Z., Pang X. B., Li Y.F. [et al.] // Talanta. – 2006. – Vol. 69, Issue 1. – P. 180–186. DOI: 10.1016/j.talanta.2005.09.022

A review on green synthesis of silver nanoparticles / Geoprincy B. N., Vidhya Srri U., Poonguzhali N. [et al.] // Asian Journal of Pharmaceutical and Clinical Research. – 2013. – Vol 6, Suppl 1. – P. 8–12.

A rich source of potential bioactive compounds with anticancer activities by Catharanthus roseus cambium meristematic stem cell cultures / Moon S. H., Pandurangan M., Kim D. H. [et al.] // Journal of ethnopharmacology. – 2018. – Vol. 217. – P. 107–117. DOI: 10.1016/j.jep.2018.02.021

Acaricidal, pediculicidal and larvicidal activity of synthesized ZnO nanoparticles using Momordica charantia leaf extract against blood feeding parasites / Gandhi P. R., Jayaseelan C., Mary R. R. [et al.] // Exp Parasitol. – 2017. – Vol. 181. – P. 47-56. DOI: 10.1016/j.exppara.2017.07.007

Badri N. E. Optical absorption measurement of synthesized ZnO using Ultra Violet-Visible Spectrophotometer / N. E. Badri, M. S. E. Badri, K. M. Sulieman // International Journal of Science and Research. – 2014. – Vol. 4, Issue 11. – P. 62–65.

Bhumi G. Biological synthesis of zinc oxide nanoparticles from Catharanthus roseus (L.). G. Don. Leaf extract and validation for antibacterial activity / G. Bhumi, N. Savithramma // Int J Drug Dev Res. – 2014. – Vol. 6. – P. 208–214.

Bioenergetic responses of freshwater mussels Unio tumidus to the combined effects of nano-ZnO and temperature regime / Falfushynska H. I., Gnatyshyna L. L., Ivanina A. V. [et al.] // Sci Total Environ. – 2019. – Vol. 10. – P. 1440–1450. DOI: 10.1016/j.scitotenv.2018.09.136.

Biomedical application of nanotechnology / Ramos A. P., Marcus A. E. C., Camila B. T. [et al.] // Biophys. Rev. – 2017. – Vol. 9, Issue 2. – P. 79–89. DOI: 10.1007/s12551-016-0246-2

Catharanthus roseus-mediated zinc oxide nanoparticlesagainst photocatalytic application of phenol red under UV@ 365nm. / Kalaiselvi A., Roopan S. M., Madhumitha G. [et al.] // Curr. Sci. – Vol. 111. – P. 1811–1815. DOI: 10.18520/cs/v111/i11/1811-1815

Comparison of antidiabetic effects of P. Sonchifolia, C. Roseus and M. Charantia extracts and green synthetized zno nanoparticles towards common carp model: in vitro study / Horyn O., Hrabra S., Savchyn T. [et al.] // 19th International Multidisciplinary Scientific GeoConference SGEM 2019. – P. 117-124. DOI: 10.5593/sgem2019/6.1/S24.015

Detoxification and cellular stress responses of unionid mussels Unio tumidus from two cooling ponds to combined nano-ZnO and temperature stress / Falfushynska H. I., Gnatyshyna L. L., Ivanina A. V. [et al.] // Chemosphere. – 2018. – Vol. 193. – P. 1127–1142. DOI: 10.1016/j.chemosphere.2017.11.079

Different approaches for the synthesis of zinc oxide nanoparticles / Zaheer A., Farman U-K., Sajid M. [et al.] // Open Journal of Chemistry. – 2018. – Vol. 1. – P. 19–25. DOI: 10.30538/psrp-ojc2018.0003

Dobrucka R. Biosynthesis and antibacterial activity of ZnO nanoparticles using Trifolium pratense flower extract / R. Dobrucka, J. Długaszewska // Saudi J Biol Sci. – 2016. – Vol. 23, Issue 4. – P. 517–523. DOI: 10.1016/j.sjbs.2015.05.016

Effective antimicrobial activity of Green ZnO nano particles of Catharanthus roseus / Gupta M., Tomar R. S., Kaushik S. [et al.] // Front Microbiol. – 2018. – Vol. 9. – P. 2030. DOI: 10.3389/fmicb.2018.02030

Fakhari S. Green synthesis of zinc oxide nanoparticles: a comparison / Fakhari S., Jamzad M., Fard H. K. // Green Chemistry Letters and Reviews. – 2018. – Vol. 10. – P. 19–24.

Fan Z. Zinc oxide nanostructures: synthesis and properties/ Zhiyong Fan, Jia Grace Lu // J Nanosci Nanotechnol. – 2005. – Vol. 5, Issue 10. – P. 1561–1573. DOI: 0.1166/jnn.2005.182

Flash synthesis of flower-like ZnO nanostructures by microwave-induced combustion process / Caoa Y., Liua B., Huangb R. [et al.] // Materials Letters. – 2011. – Vol.65, Issue 2). – P.160–163. DOI: 10.1016/j.matlet.2010.09.072

Green synthesis of gold nanoparticles using sumac aqueous extract and their antioxidant activity / Shabestarian H., Homayouni-Tabrizi M., Soltani M. [et al.] // Materials Research. – 2017. – Vol. 20, Issue 1. – P. 264–270. DOI: 10.1590/1980-5373-MR-2015-0694

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng / Abbai R., Mathiyalagan R., Markus J. [et al.] // Int J Nanomedicine. – 2016. – Vol. 11. – P. 3131–3143. DOI: 10.2147/IJN.S108549

Green synthesis of zinc oxide nanoparticles by celosia argentea and its characterization / Vaishnav J., Subhaa V., Kirubanandana S. [et. Al.] // Journal of Optoelectronics and Biomedical Materials. – 2017. – Vol. 9, Issue 1. – P. 59–71.

Iravani S. Green synthesis of metal nanoparticles using plants / S. Iravani // Green Chemistry. – 2011. – Vol. 13. – P. 2638–2650. DOI: 10.1039/c1gc15386b

Jamdagni P. Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity / P. Jamdagni, P. Khatri, J. S Rana // J. King Saud. Univ. Sci. – 2016. – Vol. 30. – P. 168–175. DOI: 10.1016/j.jksus.2016.10.002

Okuyama K. Preparation of nanoparticles via spray route / Kikuo Okuyama, I. Wuled Lenggoro // Chemical Engineering Science. – 2003. – Vol 58, Issue 3. – P.537–547 2003 DOI: 10.1016/S0009-2509(02)00578-X

Phytofabrication of gold nanoparticles assisted by leaves of Suaeda monoica and its free radical scavenging property / Arockiya Aarthi Rajathi F., Arumugam R., Saravanan S. [et al.] // Journal of Photochemistry and Photobiology B: Biology. – 2014. – Vol. 135. – P. 75–80. DOI: 10.1016/j.jphotobiol.2014.03.016

Ramesh R. Green syntheis of zinc oxide nanoparticles using flower extract Cassia Auriculata / R. Ramesh, A. Rajendran, M. Meenakshisundaram // Journal of NanoScience and NanoTechnology. –2014. – Vol 2, Issue 1. – P. 41–45.

Siddiqi K. S. Properties of zinc oxide nanoparticles and their activity against microbes / K. S. Siddiqi, A. ur Rahman, A. Husen // Nanoscale Res Lett. – 2018. – Vol. 13. – P. 141. DOI: 10.1186/s11671-018-2532-3

Sudhakaran S. Zinc oxide nanoparticle induced neurotoxic potential upon interaction with primary astrocytes / Sudhakaran S., Athira S. S., Mohanan P. V. // Neurotoxicology. – 2019. – Vol. 73. – P. 213-227. DOI: 10.1016/j.neuro.2019.04.008

Synthesis and characterization of zinc oxide (zno) nanoparticles using mango (mangifera indica) leaves / Ashwath Narayana B. S., Kushal P., Nasehuddin A. [rt al.] // IJRAR. – 2018. Vol. 5, Issue 3. – P. 432-439. DOI: 10.1729/Journal.18354

Toxicity of TiO2, ZnO, and SiO2 nanoparticles in human lung cells: safe-by-design development of construction materials / Remzova M., Zouzelka R., Brzicova T. [et al.] // Nanomaterials (Basel). – 2019. – Vol. 9, Issue 7. – pii: E968. DOI: 10.3390/nano9070968



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