ACHIEVEMENTS IN THE RESEARCH OF EXTRAMEDULAR HEMATOPOESIS IN THE SPLEEN

N. M. Petryk, S. O. Yastremska

Abstract


Thanks to the researches by William Houston, Magnus Falconar, Julian Evans we know that the spleen has powerful immune protection, is able to synthesize humoral immunity factors, it is the organ of detoxification, re-mobilization of iron, and it is involved in hemopoiesis. However, among all of functions, the hemopoietic function of the spleen still not fully explored. This is due to the fact that the extemedular hematopoiesis (EMH) is considered by most scientists as a manifestation of the pathological condition related to the failure of the bone marrow function, because physiologically, it completely stops after the embryonic development period and is almost uncharacteristic for the post-embryonic period. This process involves the production of mature blood cells outside the medullary bone cavity. EMH is often observed in patients with myelofibrosis, myeloproliferative disorders and hemoglobinopathy, especially with thalassemia and sickle cell anemia. The key organs of peripheral hematopoiesis that participate in EMH are spleen, liver and lymph nodes.

Today there are not enough researches on the fundamental processes and the very mechanism of EMH. The article presents an analysis of modern EMH researches based on publications on experimental hematology. During the analysis, prospective directions for further research were identified.


Keywords


spleen, extramedular hematopoiesis, erythropoiesis, hemopoietic colonies, thrombocytopoiesis

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DOI: https://doi.org/10.25128/2078-2357.19.1.19

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